Raising awareness about pathogenic genetic mutations.
focusing on cdh1 mutations and associated health conditions
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No Stomach For Cancer
University of Otago
The CDH1 gene makes epithelial cadherein protein.
e-cadherein helps neighboring cells stick together to form tissues that line surfaces and cavities of the human body
health conditions related to cdh1 genetic mutations
In 1998, scientists discovered a molecular basis for hereditary stomach cancer.
breaking new ground on the importance of broken e-cadherin proteins in gastric cancer
original publication on cdh1 mutations and stomach cancer
Gastric cancer associated with cdh1 mutations is a diffuse gastric cancer.
difficult to detect in early stages because the tumor cells do not clump together in masses
support and resources for stomach cancer patients and families
Prophylactic total gastrectomy became the recommended procedure of choice.
qualifying cdh1 mutation carriers can avoid diffuse stomach cancer by removing all stomach tissue
publication recommending total stomach removal for mutation carriers
Some patients opt for intensive surveillance instead of stomach surgery.
deciding between total gastrectomy or surveillance is a personal choice that patients should research before making
cdh1 community is very supportive and full of info
I had my stomach removed.
in June 2018, doctors at University of Chicago Medicine removed my stomach
learn more about UChicago Medicine's CDH1 program and amazing medical teams
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